Neel Singhal, MD

Assoc Professor Clin Neurology
Neurology

I am a neurologist trained in neurocritical care. I attend in the neurocritical care unit at Zuckerberg San Francisco General Hospital and UCSF. I perform basic laboratory and translational research to improve our ability to diagnose, treat, and prognosticate in patients with stroke and other critical neurologic injuries. I am building a nascent research program focused on identifying new pathways for neuroprotection and neuro-resilience by focusing on targets identified in human genome-wide association studies and on models of ischemia tolerance including the uniquely resilient Arctic ground squirrel.

Publications: 

Small RNA signatures of acute ischemic stroke in L1CAM positive extracellular vesicles.

Scientific reports

Manwani B, Brathaban N, Baqai A, Munshi Y, Ahnstedt HW, Zhang M, Arkelius K, Llera T, Amorim E, Elahi FM, Singhal NS

Suppressing mortality and curbing cellular damage by targeting VHL.

bioRxiv : the preprint server for biology

Jiang WI, Cao Y, Xue Y, Ji Y, Winer BY, Zhang M, Singhal NS, Pierce JT, Chen S, Ma DK

Neuroprotectants.

Ischemic Stroke Therapeutics

Neel S. Singhal, Raymond A. Swanson, Midori A. Yenari

ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke.

Clinical and translational medicine

Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z

Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia.

Annals of the New York Academy of Sciences

Krinock MJ, Singhal NS

Resilience to Injury: A New Approach to Neuroprotection?

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Singhal NS, Sun CH, Lee EM, Ma DK

Neuronal GDPGP1 and glycogen metabolism: friend or foe?

The Journal of cell biology

Singhal NS, Lee EM, Ma DK

Endovascular Treatment of Stroke, Oral Anticoagulant-associated Intracerebral Hemorrhage, and Treatment of Extracranial Dissection.

American journal of respiratory and critical care medicine

Thabet AM, Kottapally M, Singhal NS

Diagnosing Balamuthia mandrillaris Encephalitis With Metagenomic Deep Sequencing.

Annals of neurology

Wilson MR, Shanbhag NM, Reid MJ, Singhal NS, Gelfand JM, Sample HA, Benkli B, O'Donovan BD, Ali IK, Keating MK, Dunnebacke TH, Wood MD, Bollen A, DeRisi JL

Sarcoid polyneuropathy masquerading as chronic inflammatory demyelinating polyneuropathy.

Muscle & nerve

Singhal NS, Irodenko VS, Margeta M, Layzer RB

Balamuthia mandrillaris Meningoencephalitis and Central Nervous System Vasculitis Diagnosed by Next-Generation Sequencing of Cerebrospinal Fluid (S37.008).

Neurology

Niraj Shanbhag, Michael Wilson, Michael Reid, Neel Singhal, Barlas Benkli, Jeffrey Gelfand, Hannah Sample, Matthew Wood, Andrew Bollen, Joseph DeRisi

Effect of rituximab in patients with leucine-rich, glioma-inactivated 1 antibody-associated encephalopathy.

JAMA neurology

Irani SR, Gelfand JM, Bettcher BM, Singhal NS, Geschwind MD

A practical approach to neurologic evaluation in the intensive care unit.

Journal of critical care

Singhal NS, Josephson SA

Unconscious processing of color and form in metacontrast masking.

Attention, perception & psychophysics

Ro T, Singhal NS, Breitmeyer BG, Garcia JO

Inhibition of ADRP prevents diet-induced insulin resistance.

American journal of physiology. Gastrointestinal and liver physiology

Varela GM, Antwi DA, Dhir R, Yin X, Singhal NS, Graham MJ, Crooke RM, Ahima RS

Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice.

American journal of physiology. Endocrinology and metabolism

Singhal NS, Patel RT, Qi Y, Lee YS, Ahima RS

Hypothalamic control of energy homeostasis.

Neurobiology of Obesity

Neel S. Singhal, Rexford S. Ahima

Central resistin induces hepatic insulin resistance via neuropeptide Y.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Singhal NS, Lazar MA, Ahima RS

Brain adipocytokine action and metabolic regulation.

Diabetes

Ahima RS, Qi Y, Singhal NS, Jackson MB, Scherer PE

Loss of resistin improves glucose homeostasis in leptin deficiency.

Diabetes

Qi Y, Nie Z, Lee YS, Singhal NS, Scherer PE, Lazar MA, Ahima RS

Adipokines that link obesity and diabetes to the hypothalamus.

Progress in brain research

Ahima RS, Qi Y, Singhal NS

Feedback contributions to visual awareness in human occipital cortex.

Current biology : CB

Ro T, Breitmeyer B, Burton P, Singhal NS, Lane D

Effects of lithium chloride on induction and expression of methylphenidate sensitization.

European journal of pharmacology

Yang P, Singhal N, Modi G, Swann A, Dafny N