Jon Kleen, MD, PhD

Asst Prof Clinical Neurology
Neurology
https://kleen.ucsf.edu/

Dr. Jon Kleen is a neurologist who specializes in epilepsy care. He is dedicated to improving the lives of patients with epilepsy by stopping seizures and finding new ways to overcome epilepsy-related cognitive issues, such as memory problems.

Kleen is a neuroscientist with expertise in signal processing (the use of computers to study patterns in large amounts of data), which he applies to cutting-edge diagnostic approaches and emerging therapies for epilepsy, including brain stimulation. As part of his research, he investigates how memory circuits work in the human brain and why they are disrupted in many people with epilepsy. He also develops technology that integrates brainwave recordings with brain images to help pinpoint where seizures start, with the goal of increasing the chance for future curative surgery in patients whose prior treatments failed.

Kleen is originally from rural Minnesota. He earned a doctorate in neuroscience from Dartmouth College and his medical degree from Dartmouth Medical School. At UCSF, he completed a residency in neurology, serving as chief resident, and a fellowship in epilepsy. He also completed postdoctoral training in human neurophysiology at UCSF. In 2017, he was elected by UCSF medical students for membership in UCSF's chapter of Alpha Omega Alpha for excellence in teaching.

Visit the Kleen Laboratory : kleen.ucsf.edu

Publications: 

Evaluating the feasibility of prehospital point-of-care EEG: The prehospital implementation of rapid EEG (PHIRE) study.

Journal of the American College of Emergency Physicians open

Guterman EL, Mercer MP, Wood AJ, Amorim E, Kleen JK, Gerard D, Kellison C, Yamashita S, Auerbach B, Joshi N, Sporer KA

Development and validation of a nonverbal consensus-based semantic memory paradigm in patients with epilepsy.

Journal of the International Neuropsychological Society : JINS

Tran EB, Vonk JMJ, Casaletto K, Zhang D, Christin R, Marathe S, Gorno-Tempini ML, Chang EF, Kleen JK

Interictal epileptiform discharges contribute to word-finding difficulty in epilepsy through multiple cognitive mechanisms.

Epilepsia

Silva AB, Leonard MK, Oganian Y, D'Esopo E, Krish D, Kopald B, Tran EB, Chang EF, Kleen JK

Ictal EEG Source Imaging With Supplemental Electrodes.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

Loube DK, Tan YL, Yoshii-Contreras J, Kleen J, Rao VR, Chang EF, Knowlton RC

Clinical Reasoning: A Young Adult with New Seizures and Chapeau de Gendarme.

Neurology

Valdrighi A, Douglas A, Knowlton RC, Shah M, Kleen J

Intact speech perception after resection of dominant hemisphere primary auditory cortex for the treatment of medically refractory epilepsy: illustrative case.

Journal of neurosurgery. Case lessons

Hullett PW, Kandahari N, Shih TT, Kleen JK, Knowlton RC, Rao VR, Chang EF

Bidirectional propagation of low frequency oscillations over the human hippocampal surface.

Nature communications

Kleen JK, Chung JE, Sellers KK, Zhou J, Triplett M, Lee K, Tooker A, Haque R, Chang EF

Accuracy of omni-planar and surface casting of epileptiform activity for intracranial seizure localization.

Epilepsia

Kleen JK, Speidel BA, Baud MO, Rao VR, Ammanuel SG, Hamilton LS, Chang EF, Knowlton RC

Measuring synchrony in bio-medical timeseries.

Chaos (Woodbury, N.Y.)

Leguia MG, Rao VR, Kleen JK, Baud MO

Early seizure spread and epilepsy surgery: A systematic review.

Epilepsia

Andrews JP, Ammanuel S, Kleen J, Khambhati AN, Knowlton R, Chang EF

Interictal Epileptiform Discharges and the Quality of Human Intracranial Neurophysiology Data.

Frontiers in human neuroscience

Ammanuel SG, Kleen JK, Leonard MK, Chang EF

Prospective validation study of an epilepsy seizure risk system for outpatient evaluation.

Epilepsia

Chiang S, Goldenholz DM, Moss R, Rao VR, Haneef Z, Theodore WH, Kleen JK, Gavvala J, Vannucci M, Stern JM

Unsupervised Learning of Spatiotemporal Interictal Discharges in Focal Epilepsy.

Neurosurgery

Baud MO, Kleen JK, Anumanchipalli GK, Hamilton LS, Tan YL, Knowlton R, Chang EF

Multi-day rhythms modulate seizure risk in epilepsy.

Nature communications

Baud MO, Kleen JK, Mirro EA, Andrechak JC, King-Stephens D, Chang EF, Rao VR

The nociferous influence of interictal discharges on memory.

Brain : a journal of neurology

Kleen JK, Kirsch HE

Chronic ambulatory electrocorticography from human speech cortex.

NeuroImage

Rao VR, Leonard MK, Kleen JK, Lucas BA, Mirro EA, Chang EF

Progress in Epilepsy: Latest Waves of Discovery.

JAMA neurology

Kleen JK, Lowenstein DH

Injection Therapy for Headache and Facial Pain.

Oral and maxillofacial surgery clinics of North America

Kleen JK, Levin M

Oscillation Phase Locking and Late ERP Components of Intracranial Hippocampal Recordings Correlate to Patient Performance in a Working Memory Task.

Frontiers in human neuroscience

Kleen JK, Testorf ME, Roberts DW, Scott RC, Jobst BJ, Holmes GL, Lenck-Santini PP

Regulatory T cells are not a strong predictor of survival for patients with glioblastoma.

Neuro-oncology

Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE

Hippocampal interictal epileptiform activity disrupts cognition in humans.

Neurology

Kleen JK, Scott RC, Holmes GL, Roberts DW, Rundle MM, Testorf M, Lenck-Santini PP, Jobst BC

Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kleen JK, Wu EX, Holmes GL, Scott RC, Lenck-Santini PP

Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex.

Epilepsy & behavior : E&B

Kleen JK, Sesqué A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott RC

Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model.

Epilepsia

Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL

Taming TLR4 may ease seizures.

Nature medicine

Kleen JK, Holmes GL

Hippocampal interictal spikes disrupt cognition in rats.

Annals of neurology

Kleen JK, Scott RC, Holmes GL, Lenck-Santini PP

Brain inflammation initiates seizures.

Nature medicine

Kleen JK, Holmes GL

Combination of high fat diet and chronic stress retracts hippocampal dendrites.

Neuroreport

Baran SE, Campbell AM, Kleen JK, Foltz CH, Wright RL, Diamond DM, Conrad CD