Jeffrey Gelfand, MD

Professor of Clin Neurology
M_Neurology
+1 415 502-7215

Dr. Gelfand is a Professor of Neurology at UCSF. He specializes in caring for patients with a wide range of neuroinflammatory and neurodegenerative disorders. Dr. Gelfand conducts clinical research, including clinical trials, focused on advancing new treatments and restoring neurological function. Dr. Gelfand is also an award-winning medical educator.

Dr. Gelfand received an A.B. in history from Princeton University, graduating summa cum laude and Phi Beta Kappa. He received his M.D. from Harvard Medical School. He completed an internship in internal medicine, a residency in neurology, and subspecialty fellowship training in MS / Neuroimmunology, all at UCSF. Dr. Gelfand went on to earn a Master's degree in clinical research at UCSF. He is board-certified in Neurology.

Dr. Gelfand serves as Medical Director of the UCSF MS and Neuroinflammation Clinic. Dr. Gelfand is also the clinical director of the UCSF Center for Encephalitis and Meningitis (CEM). He co-directs the Specialty Practice Ambulatory Sub-Internship (SPAN) clerkship that all UCSF medical students complete as a graduation requirement. Dr. Gelfand is a recipient of the Robert B. Layzer teaching award, which is voted on annually by UCSF Neurology Department residents; an Excellence in Teaching Award from the UCSF Haile T. Debas Academy of Medical Educators; and was inducted into the UCSF Haile T. Debas Academy of Medical Educators. For over a decade (through 2023), Dr. Gelfand served as the Program Director of the UCSF MS Center Clinical Fellowship Training Program, helping to train a new generation of specialists in the field.

Dr. Gelfand is a Fellow of the American Academy of Neurology (FAAN) and served as the elected Chair of the American Academy of Neurology Autoimmune Neurology section.

Publications

Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency.

Science translational medicine

Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, Bartley CM, Kondapavulur S, Hurabielle C, Bodansky A, Pai V, Hinman S, Aslanpour A, Alvarenga BD, Zorn KC, Zamecnik C, McCann A, Asencor AI, Huynh T, Browne W, Tubati A, Haney MS, Douglas VC, Louine M, Cree BAC, Hauser SL, Seeley W, Baranzini SE, Wells JA, Spudich S, Farhadian S, Ramachandran PS, Gillum L, Hales CM, Zikherman J, Anderson MS, Yazdany J, Smith B, Nath A, Suh G, Flanagan EP, Green AJ, Green R, Gelfand JM, DeRisi JL, Pleasure SJ, Wilson MR

An autoantibody signature predictive for multiple sclerosis.

Nature medicine

Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Kizer K, Augusto DG, Tubati A, Gomez R, Fouassier C, Gerungan C, Caspar CM, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Sabatino JJ, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BAC, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR

Detection of High-Risk Paraneoplastic Antibodies Against TRIM9 and TRIM67 proteins.

Annals of neurology

Bartley CM, Ngo TT, Do LD, Zekeridou A, Dandekar R, Muñiz-Castrillo S, Alvarenga BD, Zorn KC, Tubati A, Pinto AL, Browne WD, Hullett PW, Terrelonge M, Schubert RD, Piquet AL, Binxia Y, Montalvo Perero MJ, Kung AF, Mann SA, Shah MP, Geschwind MD, Gelfand JM, DeRisi JL, Pittock SJ, Honnorat J, Pleasure SJ, Wilson MR

A Predictive Autoantibody Signature in Multiple Sclerosis.

medRxiv : the preprint server for health sciences

Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Tubati A, Gomez R, Fouassier C, Gerungan C, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BA, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR

Association of Daily Physical Activity with Cervical Spinal Cord Areas in Multiple Sclerosis.

Multiple sclerosis and related disorders

Valerie J Block, Shuiting Cheng, Jeremy Juwono, Richard Cuneo, Gina Kirkish, Amber M Alexander, Mahir Khan, Amit Akula, Eduardo Caverzasi, Nico Papinutto, William A Stern, San Francisco MS-EPIC Team University of California, Mark J Pletcher, Greg M Marcus, Jeffrey E Olgin, Stephen L Hauser, Jeffrey M Gelfand, Riley Bove, Bruce AC Cree, Roland G Henry

Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity.

Proceedings of the National Academy of Sciences of the United States of America

Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von B?dingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Or A

Autoimmune Encephalitis Misdiagnosis in Adults.

JAMA neurology

Flanagan EP, Geschwind MD, Lopez-Chiriboga AS, Blackburn KM, Turaga S, Binks S, Zitser J, Gelfand JM, Day GS, Dunham SR, Rodenbeck SJ, Clardy SL, Solomon AJ, Pittock SJ, McKeon A, Dubey D, Zekeridou A, Toledano M, Turner LE, Vernino S, Irani SR

Spinal cord atrophy predicts progressive disease in relapsing multiple sclerosis.

Annals of neurology

Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono J, Bevan CJ, Bove RM, Crabtree E, Gelfand JM, Goodin DS, Graves JS, Green AJ, Oksenberg JR, Waubant E, Wilson MR, Zamvil SS, University of California, San Francisco MS-EPIC Team, Cree BA, Hauser SL, Henry RG

Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors.

Journal for immunotherapy of cancer

Guidon AC, Burton LB, Chwalisz BK, Hillis J, Schaller TH, Amato AA, Betof Warner A, Brastianos PK, Cho TA, Clardy SL, Cohen JV, Dietrich J, Dougan M, Doughty CT, Dubey D, Gelfand JM, Guptill JT, Johnson DB, Juel VC, Kadish R, Kolb N, LeBoeuf NR, Linnoila J, Mammen AL, Martinez-Lage M, Mooradian MJ, Naidoo J, Neilan TG, Reardon DA, Rubin KM, Santomasso BD, Sullivan RJ, Wang N, Woodman K, Zubiri L, Louv WC, Reynolds KL

UpToDate

Manifestations of systemic lupus erythematosus affecting the peripheral nervous system.

Jeffrey M. Gelfand, Jinoos Yazdany.

UpToDate

Neurologic and neuropsychiatric manifestations of systemic lupus erythematosus.

Jeffrey M. Gelfand, Jinoos Yazdany.

Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis.

Science immunology

Pröbstel AK, Zhou X, Baumann R, Wischnewski S, Kutza M, Rojas OL, Sellrie K, Bischof A, Kim K, Ramesh A, Dandekar R, Greenfield AL, Schubert RD, Bisanz JE, Vistnes S, Khaleghi K, Landefeld J, Kirkish G, Liesche-Starnecker F, Ramaglia V, Singh S, Tran EB, Barba P, Zorn K, Oechtering J, Forsberg K, Shiow LR, Henry RG, Graves J, Cree BAC, Hauser SL, Kuhle J, Gelfand JM, Andersen PM, Schlegel J, Turnbaugh PJ, Seeberger PH, Gommerman JL, Wilson MR, Schirmer L, Baranzini SE

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.

The New England journal of medicine

Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY

Silent progression in disease activity-free relapsing multiple sclerosis.

Annals of neurology

Cree BAC, Hollenbach JA, Bove R, Kirkish G, Sacco S, Caverzasi E, Bischof A, Gundel T, Zhu AH, Papinutto N, Stern WA, Bevan C, Romeo A, Goodin DS, Gelfand JM, Graves J, Green AJ, Wilson MR, Zamvil SS, Zhao C, Gomez R, Ragan NR, Rush GQ, Barba P, Santaniello A, Baranzini SE, Oksenberg JR, Henry RG, Hauser SL

Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing.

JAMA neurology

Wilson MR, O'Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL

Long-term evolution of multiple sclerosis disability in the treatment era.

Annals of neurology

Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves J, Green AJ, Mowry E, Okuda DT, Pelletier D, von Büdingen HC, Zamvil SS, Agrawal A, Caillier S, Ciocca C, Gomez R, Kanner R, Lincoln R, Lizee A, Qualley P, Santaniello A, Suleiman L, Bucci M, Panara V, Papinutto N, Stern WA, Zhu AH, Cutter GR, Baranzini S, Henry RG, Hauser SL

A clinical approach to diagnosis of autoimmune encephalitis.

The Lancet. Neurology

Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, Cortese I, Dale RC, Gelfand JM, Geschwind M, Glaser CA, Honnorat J, Höftberger R, Iizuka T, Irani SR, Lancaster E, Leypoldt F, Prüss H, Rae-Grant A, Reindl M, Rosenfeld MR, Rostásy K, Saiz A, Venkatesan A, Vincent A, Wandinger KP, Waters P, Dalmau J

Neurosarcoidosis

In: Samuels M, editor. Scientific American Neurology.

Gelfand JM
Stern BJ

The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, Shigemitsu H, Culver DA, Gelfand J, Valeyre D, Sweiss N, Crouser E, Morgenthau AS, Lower EE, Azuma A, Ishihara M, Morimoto S, Tetsuo Yamaguchi T, Shijubo N, Grutters JC, Rosenbach M, Li HP, Rottoli P, Inoue Y, Prasse A, Baughman RP, Organ Assessment Instrument Investigators TW

Neurology Now

Should I see a neurologist for sarcoidosis?

Gelfand JM