Neel Singhal, MD

Assoc Professor Clin Neurology

M_Neurology

I am a neurologist trained in neurocritical care. I attend in the neurocritical care unit at Zuckerberg San Francisco General Hospital and UCSF. I perform basic laboratory and translational research to improve our ability to diagnose, treat, and prognosticate in patients with stroke and other critical neurologic injuries. My discovery research program aims to identify new pathways for neuroprotection and neuro-resilience by focusing on targets identified in human genome-wide association studies and on models of ischemia tolerance including the uniquely resilient Arctic ground squirrel. My pre-clinical translational program is focused on the use of multi-omic biomarkers to gain clues about new treatments for brain injury and neuro-recovery. My collaborative research in neurodegenerative disease brings together our laboratories expertise in mouse models with state-of-the-art CRISPR-based treatments (Clelland and Ma Labs) to work towards a cure for genetic neurological diseases.

Publications

Discovery research in physiologically maintained deceased.

Science (New York, N.Y.)

Pet DB, Parent B, Singhal NS, Clelland CD

Neurological Injury in Comatose Patients Following Substance-Use-Related Out-of-Hospital Cardiac Arrest: A Retrospective Cohort Study in a Safety Net Hospital.

Neurocritical care

Shih JJ, Otero M, Gandhi S, Talbott J, Zhou B, Vitt JR, Singhal NS, Randazzo D, Scheffler A, Hemphill JC, Amorim E

Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium.

medRxiv : the preprint server for health sciences

LaHue SC, Takegami N, Simmasalam R, Baqai A, Munoz E, Sikri A, de Courson TDB, Singhal NS, Eckalbar W, Langelier CR, Hendrickson CM, Calfee CS, Erle DJ, Krummel MF, Woodruff PG, Oskotsky T, Sirota M, Ferguson A, Douglas VC, Newman JC, Pleasure SJ, Wilson MR, COMET consortium, Singhal NS

Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium

Medrxiv

Sara C. LaHue, Naoki Takegami, Rubinee Simmasalam, Abiya Baqai, Elena Munoz, Anya Sikri, Thibault du Buisson de Courson, Nilika S. Singhal, Walter Eckalbar, Charles R. Langelier, Carolyn M. Hendrickson, Carolyn S. Calfee, David J. Erle, Matthew F. Krummel, Prescott G. Woodruff, Tomiko Oskotsky, Marina Sirota, Adam Ferguson, Vanja C. Douglas, John C. Newman, Samuel J. Pleasure, Michael R. Wilson, COMET consortium, Neel S. Singhal

Abstract DP14: Neuroinflammatory mechanisms linking metabolic syndrome with vascular cognitive impairment.

Stroke

Mengqi Zhang, Anudari Letian, Emily Goldberg, Kajsa Arkelius, NEEL SINGHAL

Abstract TP380: TMEM97 and Lipid Metabolism: Unraveling Post-Stroke Lipid Regulation.

Stroke

Kajsa Arkelius, Seok Joon Won, Lavanya Gupta, Mengqi Zhang, Raymond Swanson, NEEL SINGHAL

Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.

Proceedings of the National Academy of Sciences of the United States of America

Jiang WI, Cao Y, Xue Y, Ji Y, Winer BY, Chandra R, Zhang XF, Zhang M, Singhal NS, Pierce JT, Chen S, Ma DK

Small RNA signatures of acute ischemic stroke in L1CAM positive extracellular vesicles.

Scientific reports

Manwani B, Brathaban N, Baqai A, Munshi Y, Ahnstedt HW, Zhang M, Arkelius K, Llera T, Amorim E, Elahi FM, Singhal NS

PATJ regulates cell stress responses and vascular remodeling post-stroke

Biorxiv

Zhang M, Jiang W, Arkelius, KA, Swanson RA, Ma DK, Singhal NS

Neuroprotectants.

Ischemic Stroke Therapeutics

Neel S. Singhal, Raymond A. Swanson, Midori A. Yenari

ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke.

Clinical and translational medicine

Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z

Abstract TP251: CRISPR-engineered Mouse Neural Cells Expressing An Optimized Manf Variant Reveals Mechanisms Of MANF Neuroprotection.

Stroke

Ted D Llera, Neel S Singhal, Dengke Ma

Management of Status Epilepticus and Indications for Inpatient Electroencephalography Monitoring.

Neurologic clinics

Fan JM, Singhal NS, Guterman EL

Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia.

Annals of the New York Academy of Sciences

Krinock MJ, Singhal NS

Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells.

eLife

Singhal NS, Bai M, Lee EM, Luo S, Cook KR, Ma DK

Resilience to Injury: A New Approach to Neuroprotection?

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Singhal NS, Sun CH, Lee EM, Ma DK

Neuronal GDPGP1 and glycogen metabolism: friend or foe?

The Journal of cell biology

Singhal NS, Lee EM, Ma DK

Abstract TP110: Dissecting the Optimized Cytoprotective Responses of Arctic Ground Squirrels With CRISPR.

Stroke

Evan M Lee, Neel S Singhal, Meirong Bai, Dengke K Ma

Endovascular Treatment of Stroke, Oral Anticoagulant-associated Intracerebral Hemorrhage, and Treatment of Extracranial Dissection.

American journal of respiratory and critical care medicine

Thabet AM, Kottapally M, Singhal NS

Balamuthia mandrillaris Meningoencephalitis and Central Nervous System Vasculitis Diagnosed by Next-Generation Sequencing of Cerebrospinal Fluid (S37.008).

Neurology

Niraj Shanbhag, Michael Wilson, Michael Reid, Neel Singhal, Barlas Benkli, Jeffrey Gelfand, Hannah Sample, Matthew Wood, Andrew Bollen, Joseph DeRisi

Publications

Discovery research in physiologically maintained deceased.

Neurological Injury in Comatose Patients Following Substance-Use-Related Out-of-Hospital Cardiac Arrest: A Retrospective Cohort Study in a Safety Net Hospital.

Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium.

Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium

Abstract DP14: Neuroinflammatory mechanisms linking metabolic syndrome with vascular cognitive impairment.

Abstract TP380: TMEM97 and Lipid Metabolism: Unraveling Post-Stroke Lipid Regulation.

Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.

Small RNA signatures of acute ischemic stroke in L1CAM positive extracellular vesicles.

PATJ regulates cell stress responses and vascular remodeling post-stroke

Neuroprotectants.

ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke.

Abstract TP251: CRISPR-engineered Mouse Neural Cells Expressing An Optimized Manf Variant Reveals Mechanisms Of MANF Neuroprotection.

Management of Status Epilepticus and Indications for Inpatient Electroencephalography Monitoring.

Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia.

Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells.

Resilience to Injury: A New Approach to Neuroprotection?

Neuronal GDPGP1 and glycogen metabolism: friend or foe?

Abstract TP110: Dissecting the Optimized Cytoprotective Responses of Arctic Ground Squirrels With CRISPR.

Endovascular Treatment of Stroke, Oral Anticoagulant-associated Intracerebral Hemorrhage, and Treatment of Extracranial Dissection.

Diagnosing Balamuthia mandrillaris Encephalitis With Metagenomic Deep Sequencing.

Sarcoid polyneuropathy masquerading as chronic inflammatory demyelinating polyneuropathy.

Immediate Hemorrhagic Transformation After Intravenous Tissue-Type Plasminogen Activator Injection in 2 Cocaine Users.

Balamuthia mandrillaris Meningoencephalitis and Central Nervous System Vasculitis Diagnosed by Next-Generation Sequencing of Cerebrospinal Fluid (S37.008).

Effect of rituximab in patients with leucine-rich, glioma-inactivated 1 antibody-associated encephalopathy.

A practical approach to neurologic evaluation in the intensive care unit.

Unconscious processing of color and form in metacontrast masking.

Inhibition of ADRP prevents diet-induced insulin resistance.

Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice.

Hypothalamic control of energy homeostasis.

Central resistin induces hepatic insulin resistance via neuropeptide Y.

Brain adipocytokine action and metabolic regulation.

Loss of resistin improves glucose homeostasis in leptin deficiency.

Adipokines that link obesity and diabetes to the hypothalamus.

Unconscious color priming occurs at stimulus- not percept-dependent levels of processing.

Feedback contributions to visual awareness in human occipital cortex.

Effects of lithium chloride on induction and expression of methylphenidate sensitization.